We evaluated the effect of ciprofloxacin, 500mg given orally every 12hours, on the prevention of bacterial infections in 40 patients receiving anticancer chemotherapy for acute leukemia. Nineteen patients were randomly assigned to receive ciprofloxacin, twenty-one patients assigned as control group did not receive any prophylactic antibiotics.
The rate of febrile episodes, microbiologically documented infection, clinically documented infection, possible infection, and mortality were similar in the two groups. There were no significant difference in the duration of granulocytopenia, use of parenteral antibiotics.
Although streptococcal bacteremia occurred in only ciprofloxacin group(2cases), and gram-negative bacteremia occurred in only control group(4 cases), no difference was seen statistically.
Two patients who received ciprofloxacin showed increased SGOT/SGPT during treatment.
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